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1. 发明申请

WO2008092011A2 BIOFILM-INHIBITING MEDICAL PRODUCTS 审中-公开
标题翻译：生物膜抑制医疗产品
公开(公告)号：WO2008092011A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051924
申请日：2008-01-24
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
发明人： BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
IPC分类号： A61L26/00
CPC分类号： A61L15/44 , A61L15/40 , A61L26/0057 , A61L26/0066 , A61L31/005 , A61L31/16 , A61L2300/216 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

2. 发明申请

WO2008067085A2 PROCESSED ECM MATERIALS WITH ENHANCED COMPONENT PROFILES 审中-公开
标题翻译：加工的ECM材料与增强的组件型材
公开(公告)号：WO2008067085A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/082238
申请日：2007-10-23
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad, E.
发明人： JOHNSON, Chad, E.
IPC分类号： A61L27/36
CPC分类号： A61L27/3633 , A61L27/3604 , A61L27/3695
摘要： Described are medical graft materials and devices having improved properties relating to their component profiles.
摘要翻译：描述了具有改进的与其组分轮廓相关的性质的医用移植材料和装置。

3. 发明申请

WO2007076508A2 IMPLANTABLE GRAFT MATERIAL 审中-公开
标题翻译：可植入材料
公开(公告)号：WO2007076508A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/062619
申请日：2006-12-27
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad, E. , HILES, Michael, C.
发明人： JOHNSON, Chad, E. , HILES, Michael, C.
IPC分类号： A61F2/00
CPC分类号： A61F2/2415 , A61B90/90 , A61B2050/0065 , A61F2/0095 , A61F2/07 , A61F2/08 , A61F2/2412 , A61F2/2475 , A61F2/32 , A61F2/3603 , A61F2/40 , A61F2/86 , A61F2002/072 , A61F2002/30062 , A61F2002/30247 , A61F2002/3025 , A61F2002/30649 , A61F2002/30754 , A61F2002/30971 , A61F2002/4007 , A61F2210/0004 , A61F2230/0071 , A61F2240/001 , A61F2310/00365 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3804 , A61L27/3843 , A61L31/005
摘要： Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient's body.
摘要翻译：描述了适合于在患者体内植入的移植材料，包括在体腔中改造的分离的组织材料。还描述了治疗患者的方法，所述方法包括将这些材料植入，以及在患者体内包括这些材料的假体装置。

4. 发明申请

WO2020206410A1 METHODS OF USING MUSCARINIC ANTAGONISTS IN THE TREATMENT OF DEPRESSION 审中-公开
公开(公告)号：WO2020206410A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026820
申请日：2020-04-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE MCLEAN HOSPITAL CORPORATION , UNIVERSITY OF TEXAS, SAN ANTONIO , COOP, Andrew , JOHNSON, Chad R. , BERGMAN, Jack , KANGAS, Brian D. , WOODS, James H. , JUITKIEWICZ, Emily M. , WINGER, Gail
发明人： COOP, Andrew , JOHNSON, Chad R. , BERGMAN, Jack , KANGAS, Brian D. , WOODS, James H. , JUITKIEWICZ, Emily M. , WINGER, Gail
IPC分类号： C07D413/04 , A61K31/445 , A61K31/44
摘要： Muscarinic antagonist are provided that are used in the treatment of depression in a subject, such as humans. The muscarinic antagonist of the invention can relieve depression without effecting cognitive functions in the treated subject.

5. 发明申请

WO2011150055A3 METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS 审中-公开
标题翻译：方法，基质和系统用于细胞接种医疗用品
公开(公告)号：WO2011150055A3
公开(公告)日：2012-07-12
申请号：PCT/US2011037897
申请日：2011-05-25
申请人： COOK BIOTECH INC , MUFFIN INC , COOK MEDICAL TECHNOLOGIES LLC , HILES MICHAEL C , JOHNSON CHAD E , FEARNOT NEAL E , PAYNE THOMAS , JANKOWSKI RONALD
发明人： HILES MICHAEL C , JOHNSON CHAD E , FEARNOT NEAL E , PAYNE THOMAS , JANKOWSKI RONALD
IPC分类号： A61L27/38 , A61L27/24 , C12M3/00 , C12N5/00
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

6. 发明申请

WO2011035138A1 DUAL HOPPER ASSEMBLY 审中-公开
标题翻译：双ER ER
公开(公告)号：WO2011035138A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049304
申请日：2010-09-17
申请人： HID GLOBAL CORPORATION , MEIER, James, R. , STANGLER, Jeff , JOHNSON, Chad
发明人： MEIER, James, R. , STANGLER, Jeff , JOHNSON, Chad
IPC分类号： B65H3/06 , B65H3/44 , B65H1/04
CPC分类号： B65H3/0684 , B65H1/04 , B65H3/44 , B65H2405/331 , B65H2701/1914
摘要： [0065] Embodiments of the invention are directed to a dual hopper assembly (104) for use in a credential processing device (100), a credential processing device (100) that includes a dual hopper assembly (104), and methods of feeding substrates in a credential processing device (100). One embodiment of the dual hopper assembly (104) comprises an upper hopper (106) configured to support one or more card substrates (102), a lower hopper (108) configured to support one or more card substrates and an input feed roller (140). The input feed roller is positioned between the upper and lower hoppers and is movable between a first position (132), in which the input feed roller engages a bottom substrate (102A) supported in the upper hopper, and a second position (134), in which the input feed roller is displaced from the bottom substrate.
摘要翻译：本发明的实施例涉及用于证书处理设备（100）的双料斗组件（104），包括双料斗组件（104）的凭证处理设备（100）以及馈送基板的方法在凭证处理设备（100）中。双料斗组件（104）的一个实施例包括构造成支撑一个或多个卡片基板（102）的上料斗（106），配置成支撑一个或多个卡片基板的下料斗（108）和输入进给辊）。输入进给辊定位在上料斗和下料斗之间，并可在第一位置（132）之间移动，第一位置（132），输入进给辊与支撑在上料斗中的底部基座（102A）接合，第二位置（134）其中输入进给辊从底部基板移位。

7. 发明申请

WO2009155607A3 COMPOSITE EXTRACELLULAR MATRIX MATERIALS AND MEDICAL PRODUCTS FORMED THEREFROM 审中-公开
标题翻译：复合细胞基质材料和形成的医药产品
公开(公告)号：WO2009155607A3
公开(公告)日：2010-09-10
申请号：PCT/US2009048168
申请日：2009-06-22
申请人： COOK BIOTECH INC , JOHNSON CHAD E , ERNST DAVID M J , OVERBY AMY
发明人： JOHNSON CHAD E , ERNST DAVID M J , OVERBY AMY
IPC分类号： A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non- expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：在某些方面描述的是复合细胞外基质材料产品，包括与非扩张胶原材料组合的扩张胶原材料。还公开了其制备和使用方法。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

8. 发明申请

WO2007076508A3 IMPLANTABLE GRAFT MATERIAL 审中-公开
标题翻译：可植入材料
公开(公告)号：WO2007076508A3
公开(公告)日：2008-02-14
申请号：PCT/US2006062619
申请日：2006-12-27
申请人： COOK BIOTECH INC , JOHNSON CHAD E , HILES MICHAEL C
发明人： JOHNSON CHAD E , HILES MICHAEL C
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61F2/2415 , A61B90/90 , A61B2050/0065 , A61F2/0095 , A61F2/07 , A61F2/08 , A61F2/2412 , A61F2/2475 , A61F2/32 , A61F2/3603 , A61F2/40 , A61F2/86 , A61F2002/072 , A61F2002/30062 , A61F2002/30247 , A61F2002/3025 , A61F2002/30649 , A61F2002/30754 , A61F2002/30971 , A61F2002/4007 , A61F2210/0004 , A61F2230/0071 , A61F2240/001 , A61F2310/00365 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3804 , A61L27/3843 , A61L31/005
摘要： Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient's body.
摘要翻译：描述了适合于植入患者体内的移植材料，包括在体腔中重塑的分离的组织材料。还描述了治疗患者的方法，所述方法包括将这些材料植入，以及在患者体内包括这些材料的假体装置。

9. 发明申请

WO2013025940A1 ANGIOGENESIS PROMOTED BY ALPHA-KERATOSE 审中-公开
标题翻译：由ALPHA-KERATOSE促进的血管生成
公开(公告)号：WO2013025940A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/051212
申请日：2012-08-16
申请人： KERANETICS LLC , BURNETT, Luke , JOHNSON, Chad
发明人： BURNETT, Luke , JOHNSON, Chad
IPC分类号： A61K35/24 , A61K35/12 , A61K9/70 , A61K9/00
CPC分类号： A61K38/39 , A61K9/0031 , A61K9/0036 , A61K9/02 , A61K9/06 , A61K9/107 , A61K9/12
摘要： Described herein are compositions comprising alpha keratose and the ability of such compositions to promote vascularization and angiogenesis around a wound site, and methods for the use of such compositions alone or in combination with other keratin sub-fractions and non-keratin tissue scaffolds to modulate angiogenesis.
摘要翻译：本文描述的是包含α角质形成物和这种组合物在伤口部位周围促进血管形成和血管生成的能力的组合物，以及单独使用这些组合物或与其它角蛋白亚组分和非角蛋白组织支架组合以调节血管发生的方法。

10. 发明申请

WO2012050836A1 DEVICES AND METHODS FOR TREATING FISTULAE AND OTHER BODILY OPENINGS AND PASSAGEWAYS 审中-公开
标题翻译：用于处理假肢和其他身体开放和穿刺的装置和方法
公开(公告)号：WO2012050836A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053483
申请日：2011-09-27
申请人： COOK BIOTECH INCORPORATED , AGNEW, Charles, W. , DUNCAN, Mark , JOHNSON, Chad, E.
发明人： AGNEW, Charles, W. , DUNCAN, Mark , JOHNSON, Chad, E.
IPC分类号： A61L31/14 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet- like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

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